Code
APH-EGFX-01AX
Test
Active-Compendium
88342 x 1 or 88341 x 1
Clinical
Pathology
A formalin-fixed, paraffin-embedded (FFPE) tissue block is preferred specimen type or one (1) unbaked, unstained slide for H&E staining (required) and two to three (2-3) positively charged unstained slides (all cut at 4-5 microns) for each test/antibody ordered.
Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Flag Active
True
Orderable Test Description
<p>Epidermal Growth Factor Receptor (EGFR) overexpression can occur in a variety of tumor types, including breast, prostate, ovarian, brain, lung and predominantly squamous cell carcinomas. Tumors that express EGFR are associated with a poor prognosis and a shorter disease-free survival. Most colon carcinomas will show expression of EGFR in more than 1% of the invasive tumor cells. Patients whose tumor expresses EGFR and are wild-type for KRAS mutation are eligible for cetuximab therapy based on the status of RAS mutation.</p>
<p>EGFR immunohistochemistry (clone D38B1; non-mutation specific) has no relationship to determining clinical response to EGFR–tyrosine kinase inhibitors in lung adenocarcinoma. The appropriate study to evaluate somatic mutations in the tyrosine kinase domain of EGFR gene in lung adenocarcinomas is EGFR Mutation Analysis by either PCR or NGS methods.</p>
<p>EGFR immunohistochemistry (clone D38B1; non-mutation specific) has no relationship to determining clinical response to EGFR–tyrosine kinase inhibitors in lung adenocarcinoma. The appropriate study to evaluate somatic mutations in the tyrosine kinase domain of EGFR gene in lung adenocarcinomas is EGFR Mutation Analysis by either PCR or NGS methods.</p>
Orderable Turn Around Time
Global: 2 Day, Tech-Only (stain only): 1 Day
Extra Note
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. NYS clients please provide date and time of Collection.
Orderable Biomarkers
NY Approved
True
Orderable Biomarkers JSON
{"Immunohistochemistry (IHC)": {"Expression": ["EGFR"]}}
Keywords string
EGFR, EGFR IHC, EGFR expression, Epiderman growth factor receptor EGFR
Title URL
egfr