Code
APH-MSTX-01AX
Test
Active-Compendium
88342 x 1 or 88341 x 1; 88360 x 1; 88361 x 1
Clinical
Pathology
A formalin-fixed, paraffin-embedded (FFPE) tissue block is preferred specimen type or one (1) unbaked, unstained slide for H&E staining (required) and two to three (2-3) positively charged unstained slides (all cut at 4-5 microns) for each test/antibody ordered.
Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Flag Active
True
Orderable Test Description
Human mismatch repair protein 2 (MSH2) is involved in the initial recognition of mismatched nucleotides during the post replication mismatch repair process. Loss of MSH2 function leads to the accumulation of replication errors, which in turn may be responsible for the multiple mutations required for multistage carcinogenesis. Mutations in MSH2 gene is linked to hereditary nonpolyposis colon cancer and to sporadic cancers which exhibit microsatellite instability.
Orderable Turn Around Time
Global: 2 Day, Tech-Only (stain only): 1 Day
Keywords
Extra Note
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. NYS clients please provide date and time of Collection.
Orderable Biomarkers
NY Approved
True
Orderable Biomarkers JSON
{"Immunohistochemistry (IHC)": {"Expression": ["MSH2"]}}
Keywords string
MSH2, MSH2 expression, MSH2 IHC, MMR MSH2
Title URL
msh2