Code
APH-PTEX-01AX
Test
Active-Compendium
88342 x 1 or 88341 x 1; 88360 x 1
Clinical
Pathology
A formalin-fixed, paraffin-embedded (FFPE) tissue block is preferred specimen type or one (1) unbaked, unstained slide for H&E staining (required) and two to three (2-3) positively charged unstained slides (all cut at 4-5 microns) for each test/antibody ordered.
Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Flag Active
True
Orderable Test Description
Phosphatase and tensin homolog (PTEN) is a tumor suppressor gene that is mutated in a wide range of cancers. PTEN plays a role in cell proliferation, apoptosis and migration. Reduced expression of PTEN has been reported in a variety of malignancies, including breast, prostate and endometrial cancer, and may be observed in Cowden syndrome tumors. In breast and prostate cancer, loss of PTEN expression has been shown to correlate positively with advanced stage disease. Recent studies have reported that PTEN may be a powerful predictor of response to Herceptin in HER2 positive breast cancer.
Orderable Turn Around Time
Global: 2 Day, Tech-Only (stain only): 1 Day
Extra Note
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. NYS clients please provide date and time of Collection.
Orderable Biomarkers
NY Approved
True
Orderable Biomarkers JSON
{"Immunohistochemistry (IHC)": {"Expression": ["PTEN"]}}
Keywords string
PTEN, Protein Tyrosine Phosphatase, PTEN IHC, PTEN Expression PTEN
Title URL
pten