Code
APT-IGFX-01AX
Test
Active-Compendium
88342 x 1 or 88341 x 1
Clinical
Pathology
A formalin-fixed, paraffin-embedded (FFPE) tissue block is preferred specimen type or one (1) unbaked, unstained slide for H&E staining (required) and two to three (2-3) positively charged unstained slides (all cut at 4-5 microns) for each test/antibody ordered.
Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Flag Active
True
Orderable Test Description
Autoimmune pancreatitis typically produces an enlarged pancreas with narrowing of the pancreatic duct, and can mimic carcinoma. It was shown that the pancreatic tissue from patients with autoimmune pancreatitis often shows moderate or marked infiltration by IgG4-positive plasma. IgG4 staining in patients with chronic alcoholic pancreatitis and pancreatic ductal adenocarcinoma was rarely observed. IgG4-positive plasma cells are a useful marker for the tissue diagnosis of autoimmune pancreatitis. Elevated IgG4+ to IgG+ plasma cell ratio (IgG4/IgG ratio) is helpful in distinguishing IgG4-related from non IgG4-related inflammatory conditions.
Orderable Turn Around Time
1 Day
Keywords
Extra Note
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. NYS clients please provide date and time of Collection.
Orderable Biomarkers
NY Approved
True
Orderable Biomarkers JSON
{"Immunohistochemistry (IHC)": {"Expression": ["IgG4"]}}
Keywords string
IgG4, immunoglobulin G4, immunoglobulin IgG4 (Immunoglobulin G4)
Title URL
igg4-immunoglobulin-g4