TP63 Rearrangement

Code
FSH-TPSR-01BX
Test
Active-Compendium
88377x2 manual or 88374x2 automated
Clinical
Pathology
Bone Marrow Aspirate: N/A
Peripheral Blood: N/A
Fresh, Unfixed Tissue: N/A
Fluids: N/A
Paraffin Block: H&E slide (required) plus paraffin block. Circle H&E for tech-only.
Cut Slides: H&E slide (required) plus 2 unstained slides cut at 4 microns. Circle H&E for tech-only.
Flag Active
True
Orderable Test Description
Probes: TP63 (3q28) | TBL1XR1/TP63 [inv(3)(q26q28)]
Disease(s): Anaplastic large cell lymphoma (ALCL), peripheral T-cell lymphoma (PTCL)
Note: Probes are not orderable separately; concurrent analysis is necessary due to proximity of breakpoints in the most common fusion rearrangement.
Orderable Turn Around Time
3-5 Days
Keywords
Meta Description
TP63 rearrangements define a subset of ALK-negative ALCL cases associated with aggressive course and poor outcome. This FISH test includes TBL1XR1/TP63 fusion analysis.
Extra Note

Use cold pack for transport, making sure cold pack is not in direct contact with specimen. NYS clients please provide date and time of Collection.

Orderable Biomarkers
NY Approved
True
Orderable Biomarkers JSON
{"Fluorescence In Situ Hybridization (FISH)": {"Structural Rearrangement(s)": ["TP63"]}}
Keywords string
p63, Np63, delta Np63, p63 TP63 Rearrangement
Title URL
tp63-rearrangement