Lung NGS Fusion Panel (Complete or Limited)

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Code
MOG-LCFP-03AX
Test
Active-Compendium
81449
81449
Clinical
Oncology,Pathology
FFPE tissue: Paraffin block is preferred. Alternatively, send 1 H&E slide plus 5-10 unstained slides cut at 5 or more microns. Please use positively-charged slides and 10% NBF fixative. Do not use zinc fixatives.
Solid Tumors
Lung
Next Generation Sequencing (NGS)
Global
Flag Active
True
Orderable Test Description
<p>The Lung NGS Fusion Panel (Complete or Limited) is an RNA-based next-generation sequencing panel that detects translocations and fusions of the genes ALK, MET including MET Exon 14 skipping, NTRK1, NTRK2, NTRK3, NRG1, RET and ROS1 with known and novel fusion partners. Examples of some of the published fusions detectable in this test include EML4-ALK, KIF5B-ALK, NPM1-ALK, CD74-NTRK1, MPRIP-NTRK1, TPM3-NTRK1, TRIM24-NTRK2, PAN3-NTRK2, ETV6-NTRK3, CCD6-RET (aka RET-PTC1), KIF5B-RET, NCOA4-RET (aka RET-PTC3), CD74-ROS1, SLC34A2-ROS1, and TPM3-ROS1. Lung Complete NGS Fusion Panel includes all genes listed above. Clients can opt out of ALK and ROS1 testing to receive the Lung Limited NGS Fusion Panel report. This test may be used to select patients for the following FDA-approved therapies:&nbsp; ALK- ALECENSA&reg; (alectinib), XALKORI&reg; (crizotinib), ZYKADIA (ceritinib), ALUNBRIG&reg; (brigatinib), LORBRENA&reg; (lorlatinib) MET Exon 14- TABRECTA (capmatinib) NTRK- ROZLYTREK&reg; (entrectinib), VITRAKVI&reg; (larotrectinib) RET- GAVRETO (pralsetinib), RETEVMO (selpercatinib) ROS- XALKORI&reg; (crizotinib), ROZLYTREK&reg; (entrectinib)</p>
Orderable Turn Around Time
21 Days
Keywords
larotrectinib
Vitrakvi
NGSfusionsearch
Meta Description
The Lung NGS Fusion Profile (Complete or Limited) is a next-generation sequencing panel that detects known and novel fusions (translocations) of ALK, NTRK1, NTRK2, NTRK3, NRG1, RET, and ROS1 as well as point mutations and small insertion/deletion mutations in select exons of these six genes.
Extra Note

Use cold pack for transport, making sure cold pack is not in direct contact with specimen. NYS clients please provide date and time of Collection.

Orderable Biomarkers
MET exon 14 Skipping
NTRK1
MET
NTRK2
NTRK3
ROS1
ALK
NRG1
RET
NY Approved
True
Orderable Biomarkers JSON
{"RNA Sequencing": {"Fusions": ["NTRK1", "MET", "NTRK2", "NTRK3", "ROS1", "ALK", "NRG1", "RET"], "Splice Variant": ["MET exon 14 Skipping"]}}
Keywords string
Larotrectinib, Vitrakvi, NGSfusionsearch Lung NGS Fusion Panel (Complete or Limited)
Title URL
lung-ngs-fusion-panel-complete-or-limited