MLH1 Promoter Methylation Analysis

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Code
MOG-MLHX-01AX
Test
Active-Compendium
81288
Clinical
Oncology,Pathology
FFPE solid tumor tissue: Paraffin block is preferred. Alternatively, send 1 H&E slide plus 5-10 unstained slides cut at 5 or more microns. Please use positively-charged slides and 10% NBF fixative. Do not use zinc fixatives.
Solid Tumors
Colorectal
Endometrium
Molecular
Global
Flag Active
True
Orderable Test Description
This assay is performed on tumor tissue to detect hypermethylation of the MLH1 gene promoter. Bisulfite modification of tumor DNA and real-time PCR are used to quantify CpG methylation within the promoter. Percentage of methylated DNA (compared to total DNA) is reported for positive results. Analysis should be considered in combination with IHC, BRAF, and/or MSI.
Orderable Turn Around Time
10 Days
Keywords
mlh1
mlh 1
mlh 1 promoter
MLH1 methylation
Meta Description
This assay is performed on tumor tissue to detect hypermethylation of the MLH1 gene promoter. Bisulfite modification of tumor DNA and real-time PCR are used to quantify CpG methylation within the promoter. Percentage of methylated DNA (compared to total DNA) is reported for positive results.
Extra Note

Use cold pack for transport, making sure cold pack is not in direct contact with specimen. NYS clients please provide date and time of Collection.

Orderable Biomarkers
MLH1
NY Approved
True
Orderable Biomarkers JSON
{"Polymerase Chain Reaction (PCR)": {"Promoter Methylation": ["MLH1"]}}
Keywords string
mlh1, mlh 1, mlh 1 promoter, MLH1 methylation MLH1 Promoter Methylation Analysis
Title URL
mlh1-promoter-methylation-analysis