Code
MOG-PDGX-01CZ
Test
Active-Compendium
81314
Clinical
Oncology,Pathology
FFPE solid tumor tissue: Paraffin block is preferred. Alternatively, send 1 H&E slide plus 5-10 unstained slides cut at 5 or more microns. Please use positively-charged slides and 10% NBF fixative. Do not use zinc fixatives.
Flag Active
True
Orderable Test Description
Bi-directional sequencing of exons 12 and 18 of the PDGFRA (platelet-derived growth factor alpha) gene. These exons are mutation hotspots that account for the majority of PDGFRA mutations detected in gastrointestinal stromal tumors (GISTs) including the common TKI-resistance mutation D842V. Solid tumor enrichment is performed before extraction.
PDGFRA Amplification by FISH is available for detection of PDGFRA amplifications, which occur in approximately 30% of pediatric and 20% of adult high-grade astrocytomas, and may have prognostic and/or therapeutic implications.
PDGFRA Rearrangement by FISH is also available for detection of FIP1L1-PDGFRA fusion, which may be found in myeloid/lymphoid neoplasms with eosinophilia. Bone marrow and peripheral blood are acceptable specimens.
PDGFRA Amplification by FISH is available for detection of PDGFRA amplifications, which occur in approximately 30% of pediatric and 20% of adult high-grade astrocytomas, and may have prognostic and/or therapeutic implications.
PDGFRA Rearrangement by FISH is also available for detection of FIP1L1-PDGFRA fusion, which may be found in myeloid/lymphoid neoplasms with eosinophilia. Bone marrow and peripheral blood are acceptable specimens.
Orderable Turn Around Time
10 Days
Extra Note
Use cold pack for transport, making sure cold pack is not in direct contact with specimen.
Orderable Biomarkers
NY Approved
False
Orderable Biomarkers JSON
{"DNA Sequencing": {"SNVs + Indels": ["PDGFRA"]}}
Keywords string
PDGFR, PDGFR a, mutation PDGFRa Mutation Analysis
Title URL
pdgfra-mutation-analysis