TP53 Mutation Analysis

Code
MOG-TMAX-01CZ
Test
Active-Compendium
81352 (as of 01/01/2021); Prior to CPT Code was 81405
Clinical
Oncology,Pathology
Peripheral blood: 5 mL in EDTA tube.
Bone marrow: 2 mL in EDTA tube.
FFPE solid tumor tissue: Paraffin block is preferred. Alternatively, send 1 H&E slide plus 5-10 unstained slides cut at 5 or more microns. Please use positively-charged slides and 10% NBF fixative. Do not use zinc fixatives.
Note: Test is DNA-based.  Please select Extract & Hold - DNA if specimen hold service is desired.
Flag Active
True
Orderable Test Description
Bi-directional sequencing of TP53 exons 4-9.
Orderable Turn Around Time
7 Days
Meta Description
The TP53 gene encodes the tumor suppressor p53. TP53 mutations are detected in at least 50% of all adult tumors and are generally associated with a poor prognosis. For patients with chronic lymphocytic leukemia (CLL), TP53 sequencing, in addition to FISH for 17p deletion, aids in prognosis and/or therapy selection. Germline mutations in TP53 are the cause of Li-Fraumeni Syndrome.
Extra Note

Please select extract & hold - DNA if specimen hold service is desired. Use cold pack for transport, making sure cold pack is not in direct contact with specimen.

Orderable Biomarkers
NY Approved
False
Orderable Biomarkers JSON
{"DNA Sequencing": {"SNVs + Indels": ["TP53"]}}
Keywords string
TP53, TP53 Mutation Analysis, p53 TP53 Mutation Analysis
Title URL
tp53-mutation-analysis