Code
NTG-ALLX-02CX
Panel
Active-Compendium
81450x1, 88374x2
Clinical
Oncology,Pathology
Bone Marrow Aspirate: 2-3 mL in EDTA tube
Peripheral Blood: 3-5 mL in EDTA tube
FFPE tissue: Paraffin block. Alternatively, send 1 H&E slide plus 10-14 unstained slides cut at 5 or more microns. Please use positively-charged slides and 10% NBF fixative is the recommended fixative. Do not use zinc or mercury fixatives (B5). Highly acidic or prolonged decalcification processes will not yield sufficient nucleic acid to accurately perform molecular studies. Note: not validated for the FISH portion.
Note: Test in TNA-based. Please select Extract & Hold - TNA if specimen hold service is desired.
Peripheral Blood: 3-5 mL in EDTA tube
FFPE tissue: Paraffin block. Alternatively, send 1 H&E slide plus 10-14 unstained slides cut at 5 or more microns. Please use positively-charged slides and 10% NBF fixative is the recommended fixative. Do not use zinc or mercury fixatives (B5). Highly acidic or prolonged decalcification processes will not yield sufficient nucleic acid to accurately perform molecular studies. Note: not validated for the FISH portion.
Note: Test in TNA-based. Please select Extract & Hold - TNA if specimen hold service is desired.
Flag Active
True
Orderable Test Description
<p>The NeoTYPE ALL Profile analyzes 50 genes to detect DNA and RNA alterations through a combination of next-generation sequencing (NGS) and FISH as noted below. Test reports include a summary interpretation of all results together. FISH components may be ordered as "Tech-Only" by pathology clients who wish to perform the professional component. </p>
<p>DNA Sequencing: SNVs/InDels (29 Genes): ABL1, ABL2, CDKN2A, CRLF2, CSF1R, EPOR, FBXW7, FGFR2, FGFR3, FLT3, IDH1, IDH2, IKZF1, IL7R, JAK1, JAK2, JAK3, KRAS, NOTCH1, NRAS, NTRK1, NTRK2, NTRK3, PAX5, PDGFRA, PDGFRB, PHF6, SH2B3, and TP53 </p>
<p>Copy Number Variations (3 Genes): CDKN2A, IKZF1, and TP53 Note: Only copy number loss is reported as it is a clinically relevant abnormality for these tumor suppressor genes. </p>
<p>RNA Sequencing: Fusions (34 Genes): ABL1, ABL2, BCL11B, BCR, CRLF2, CSF1R, EPOR, ETV6, FGFR1, FLT3, IKZF1, JAK2, KMT2A, MEF2D, MLLT10, MYB, NTRK1, NTRK2, NTRK3, NUP214, NUP98, PAX5, PBX1, PDGFRA, PDGFRB, PTK2B, RUNX1, STIL, TAL1, TCF3, TLX1, TLX3, TYK2, and ZNF384 </p>
<p>FISH (2 Genes): CRLF2 (Xp22.33/Yp11.32) | EPOR (19p13.2)</p>
<p>DNA Sequencing: SNVs/InDels (29 Genes): ABL1, ABL2, CDKN2A, CRLF2, CSF1R, EPOR, FBXW7, FGFR2, FGFR3, FLT3, IDH1, IDH2, IKZF1, IL7R, JAK1, JAK2, JAK3, KRAS, NOTCH1, NRAS, NTRK1, NTRK2, NTRK3, PAX5, PDGFRA, PDGFRB, PHF6, SH2B3, and TP53 </p>
<p>Copy Number Variations (3 Genes): CDKN2A, IKZF1, and TP53 Note: Only copy number loss is reported as it is a clinically relevant abnormality for these tumor suppressor genes. </p>
<p>RNA Sequencing: Fusions (34 Genes): ABL1, ABL2, BCL11B, BCR, CRLF2, CSF1R, EPOR, ETV6, FGFR1, FLT3, IKZF1, JAK2, KMT2A, MEF2D, MLLT10, MYB, NTRK1, NTRK2, NTRK3, NUP214, NUP98, PAX5, PBX1, PDGFRA, PDGFRB, PTK2B, RUNX1, STIL, TAL1, TCF3, TLX1, TLX3, TYK2, and ZNF384 </p>
<p>FISH (2 Genes): CRLF2 (Xp22.33/Yp11.32) | EPOR (19p13.2)</p>
Orderable Turn Around Time
14 Days
Extra Note
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. Please select Extract & Hold - TNA if specimen hold service is desired.
Orderable Biomarkers
NY Approved
False
Orderable Biomarkers JSON
{"DNA Sequencing": {"SNVs + Indels": ["IDH1", "IDH2", "KRAS", "NRAS", "NOTCH1", "PHF6", "FBXW7", "PAX5", "ABL1", "ABL2", "CDKN2A", "CRLF2", "CSF1R", "EPOR", "FGFR2", "FGFR3", "FLT3", "IL7R", "JAK1", "IKZF1", "JAK2", "JAK3", "NTRK1", "NTRK3", "NTRK2", "PDGFRA", "PDGFRB", "SH2B3", "TP53"], "CNVs": ["CDKN2A", "IKZF1", "BCORL1", "TP53"]}, "RNA Sequencing": {"Fusions": ["MYB", "NUP98", "BCL11B", "ABL1", "ABL2", "BCR", "CRLF2", "CSF1R", "EPOR", "ETV6", "FGFR1", "FLT3", "IKZF1", "TLX3", "STIL", "MEF2D", "MLLT10", "JAK2", "NTRK2", "KMT2A", "NTRK3", "PAX5", "PBX1", "PDGFRA", "PDGFRB", "PTK2B", "RUNX1", "TAL1", "TCF3", "TLX1", "NUP214", "TYK2", "ZNF384", "NTRK1"], "Expression": ["CRLF2", "EPOR"]}, "Fluorescence In Situ Hybridization (FISH)": {"CNVs": ["CRLF2", "EPOR"]}}
Keywords string
Acute lymphoblastic leukemia, Myeloid disorders, heme cancers, hematologic malignancies NeoTYPE® ALL Profile
Title URL
neotype-all-profile