NeoTYPE® Breast Tumor Profile

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Code
NTG-BTPX-02CX
Panel
Active-Compendium
81457x1, 88377x2, 88360x1, 88342x1; add 81479x1 if reflexed to NTRK NGS Fusion Panel (default) or 88374x3 automated (88377x3 manual) if reflexed to NTRK 1-3 FISH Panel
81479
Clinical
Oncology,Pathology
FFPE tissue: Paraffin block preferred. Please use 10% buffered formalin fixative. Do not use zinc fixatives.
Solid Tumors
Breast
Next Generation Sequencing (NGS)
Global
Flag Active
True
Orderable Test Description
<p>The NeoTYPE Breast Tumor Profile analyzes 60 biomarkers through a combination of next-generation sequencing (NGS), FISH, and IHC as listed below. Test orders include summary interpretation of all results to help guide treatment decisions. If Pan-TRK IHC is expressed or equivocal, reflex to either NTRK NGS Fusion Panel (Default) or NTRK 1-3 FISH Panel will be added. A microsatellite instability (MSI) NGS result of &ldquo;indeterminate&rdquo; will create a reflex to MSI by PCR as long as the tumor percentage is &ge;40% and paired normal tissue is available. NGS (54 genes + 2 biomarkers): AKT1, ARID1A, ATM, ATR, BARD1, BRAF, BRCA1, BRCA2, BRIP1, CDH1, CDK12, CHEK1, CHEK2, CTNNB1, EGFR, ESR1, ERBB2, ERBB4, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, FANCL, FGFR1, FGFR2, FGFR3, GATA3, HRAS, KIT, KRAS, MET, Microsatellite Instability (MSI), MLH1, MRE11A (MRE11), MSH2, MSH6, NBN, NRAS, PALB2, PIK3CA, PMS2, PTEN, RAD50, RAD51, RAD51B, RAD51C, RAD51D, RAD54L, SMAD4, SMO, SRC, TERT Promoter, TP53, Tumor Mutation Burden (TMB) FISH (2 FISH): MET, PTEN (tech-only available) IHC (2 biomarkers): PD-L1 22C3, Pan-TRK (tech-only available for PD-L1).</p>
Orderable Turn Around Time
14 Days; add 1-3 Days if reflexed to NTRK NGS Fusion Profile
Keywords
breast
Tumor
profile
NeoTYPE Breast Tumor Profile
Meta Description
The NeoTYPE Breast Tumor Profile characterizes primary or metastatic breast tumors of any histological subtype for the most significant genetic changes relevant to therapy decisions, prognosis, and clinical research.
Extra Note

Use cold pack for transport, making sure cold pack is not in direct contact with specimen. NYS clients please provide date and time of Collection.

Orderable Biomarkers
PTEN
MET
PD-L1
NTRK1
NTRK2
NTRK3
TMB
MSI
HRAS
KIT
KRAS
FGFR1
NRAS
BRCA2
BRIP1
PALB2
RAD51C
BRAF
PTEN
TERT
AKT1
ARID1A
ATM
ATR
FGFR2
FGFR3
CDH1
BRCA1
CHEK1
CHEK2
BARD1
EGFR
ERBB2
CDK12
ESR1
FANCA
ERBB4
FANCD2
FANCE
CTNNB1
FANCG
FANCL
FANCC
GATA3
MET
SMO
MLH1
MRE11
FANCF
MSH6
NBN
PMS2
MSH2
RAD50
RAD51
PIK3CA
RAD51D
RAD54L
RAD51B
TP53
SRC
SMAD4
NY Approved
True
Orderable Biomarkers JSON
{"DNA Sequencing": {"SNVs + Indels": ["HRAS", "KIT", "KRAS", "FGFR1", "NRAS", "BRCA2", "BRIP1", "PALB2", "RAD51C", "BRAF", "PTEN", "TERT", "AKT1", "ARID1A", "ATM", "ATR", "FGFR2", "FGFR3", "CDH1", "BRCA1", "CHEK1", "CHEK2", "BARD1", "EGFR", "ERBB2", "CDK12", "ESR1", "FANCA", "ERBB4", "FANCD2", "FANCE", "CTNNB1", "FANCG", "FANCL", "FANCC", "GATA3", "MET", "SMO", "MLH1", "MRE11", "FANCF", "MSH6", "NBN", "PMS2", "MSH2", "RAD50", "RAD51", "PIK3CA", "RAD51D", "RAD54L", "RAD51B", "TP53", "SRC", "SMAD4"], "Genomic Signatures": ["TMB", "MSI"]}, "Immunohistochemistry (IHC)": {"Expression": ["PD-L1", "NTRK1", "NTRK2", "NTRK3"]}, "Fluorescence In Situ Hybridization (FISH)": {"Amplification(s)": ["MET"], "Deletion(s)": ["PTEN"]}}
Keywords string
Breast, Tumor, Profile, NeoTYPE Breast Tumor Profile NeoTYPE® Breast Tumor Profile
Title URL
neotype-breast-tumor-profile