Code
NTG-CLPX-02CX
Panel
Active-Compendium
88374x4; 81450x1; 81263x1 (if IgVH Mutation Analysis is added)
81479x1; 88374x4; 81263x1 (if IgVH Mutation Analysis is added)
Clinical
Oncology,Pathology
Peripheral blood: 5 mL in EDTA tube.
Bone marrow: 2 mL in EDTA tube.
Fresh tissue: 0.5 - 1 cm3 in RPMI (Note: not acceptable for NYS samples).
FFPE tissue: Paraffin block. Alternatively, send 1 H&E slide plus 10-14 unstained slides cut at 5 or more microns. Please use positively-charged slides and 10% NBF fixative is the recommended fixative. Do not use zinc or mercury fixatives (B5). Highly acidic or prolonged decalcification processes will not yield sufficient nucleic acid to accurately perform molecular studies. Note: not acceptable for IgVH Mutation Analysis if added on.
Note: Please exclude biopsy needles, blades, and other foreign objects from transport tubes. These can compromise specimen viability and yield, and create hazards for employees.
Note: Test in TNA-based. Please select Extract & Hold - TNA if specimen hold service is desired.
Bone marrow: 2 mL in EDTA tube.
Fresh tissue: 0.5 - 1 cm3 in RPMI (Note: not acceptable for NYS samples).
FFPE tissue: Paraffin block. Alternatively, send 1 H&E slide plus 10-14 unstained slides cut at 5 or more microns. Please use positively-charged slides and 10% NBF fixative is the recommended fixative. Do not use zinc or mercury fixatives (B5). Highly acidic or prolonged decalcification processes will not yield sufficient nucleic acid to accurately perform molecular studies. Note: not acceptable for IgVH Mutation Analysis if added on.
Note: Please exclude biopsy needles, blades, and other foreign objects from transport tubes. These can compromise specimen viability and yield, and create hazards for employees.
Note: Test in TNA-based. Please select Extract & Hold - TNA if specimen hold service is desired.
Flag Active
True
Orderable Test Description
<p>This NeoTYPE® CLL Profile analyzes 12 genes through next-generation sequencing (NGS) and the CLL FISH Panel as noted below. Test orders include summary interpretation of all results together. FISH components of NeoTYPE Profiles may be ordered as Tech-Only by pathology clients who wish to perform the professional component. NGS (12 genes): ATM, BCL2, BIRC3, BTK, CARD11, CD79B, CXCR4, MYD88, NOTCH1, PLCG2, SF3B1, TP53 FISH probes: 6q- [SEC63 (6q21), MYB (6q23)] | ATM (11q22.3) | p53 (17p13.1) | Trisomy 12 (Cen 12) | 13q-/-13 (13q14, 13q34) | CCND1/IgH t(11;14) Optional Add-on: IgVH Mutation Analysis.</p>
Orderable Turn Around Time
14 Days
Extra Note
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. NYS clients please provide date and time of Collection. Please select Extract & Hold - TNA if specimen hold service is desired.
Orderable Biomarkers
NY Approved
True
Orderable Biomarkers JSON
{"DNA Sequencing": {"SNVs + Indels": ["BCL2", "BIRC3", "BTK", "CARD11", "CD79B", "CXCR4", "MYD88", "NOTCH1", "PLCG2", "SF3B1", "ATM", "TP53"]}, "Fluorescence In Situ Hybridization (FISH)": {"Translocation(s)": ["t(11;14)"], "Aberration(s)": ["Trisomy 12"], "CNVs": ["Chromosome 17", "Trisomy 13"]}}
Keywords string
precision profile, solid tumors, neo type, NeoTYPE Precision Profile for Solid Tumors. NeoTYPE® CLL Profile
Title URL
neotype-cll-profile