Code
NTG-CTPX-02CX
Panel
Active-Compendium
81457x1, 88377x3, 88360x2, 88342x1; add 88374x1 if HER2 IHC is reflexed to FISH; add 81479x1 if reflexed to NTRK NGS Fusion Panel (default) or 88374x3 automated (88377x3 manual) if reflexed to NTRK 1-3 FISH Panel
81479
Clinical
Oncology,Pathology
FFPE tissue: Paraffin block preferred. Please use 10% buffered formalin fixative. Do not use zinc fixatives.
Flag Active
True
Orderable Test Description
<p>The NeoTYPE Colorectal Tumor Profile analyzes 44 biomarkers through a combination of next-generation sequencing (NGS), other molecular methods, FISH, and IHC as listed below. Test orders include summary interpretation of all results to help guide treatment decisions. If global HER2 (Other) IHC w/Gastric Scoring result is 2+, case will reflex to global HER2 (Other) FISH w/ Gastric Scoring unless reflex to tech-only FISH or reflex opt-out is requested. If Pan-TRK IHC is expressed or equivocal, reflex to either NTRK NGS Fusion Panel (Default) or NTRK 1-3 FISH Panel will be added. A microsatellite instability (MSI) NGS result of "indeterminate" will create a reflex to MSI by PCR as long as the tumor percentage is ≥20%. NGS (36 genes + 2 biomarkers): AKT1, ARID1A, APC, ATM, BRAF, EGFR, EPCAM, ERBB2, ERBB4, FBXW7, FGFR1, FGFR2, FGFR3, HRAS, KIT, KRAS, MET, Microsatellite Instability (MSI), MLH1, MSH2, MSH6, MUTYH, NOTCH1, NRAS, PDGFRA, PIK3CA, PMS2, POLD1, POLE, PTEN, RNF43, SMAD4, SMO, SRC, STK11, TERT Promoter, TP53, Tumor Mutation Burden (TMB) FISH (3 FISH): MET, PTEN, RET (tech-only available) IHC (3 biomarkers): HER2 (Other) w/Gastric Scoring, PD-L1 LDT, Pan-TRK (tech-only available for HER2 and PD-L1).</p>
Orderable Turn Around Time
14 Days; add 1-3 Days if reflexed to NTRK NGS Fusion Profile
Extra Note
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. NYS clients please provide date and time of Collection.
Orderable Biomarkers
NY Approved
True
Orderable Biomarkers JSON
{"DNA Sequencing": {"SNVs + Indels": ["HRAS", "KIT", "KRAS", "NRAS", "NOTCH1", "EPCAM", "FBXW7", "MUTYH", "POLD1", "POLE", "RNF43", "STK11", "TERT", "AKT1", "ARID1A", "ATM", "FGFR2", "FGFR3", "EGFR", "ERBB2", "ERBB4", "SMAD4", "FGFR1", "MET", "SMO", "MLH1", "MSH2", "MSH6", "PDGFRA", "PIK3CA", "PMS2", "PTEN", "APC", "TP53", "SRC", "BRAF"], "Genomic Signatures": ["MSI", "TMB"]}, "Fluorescence In Situ Hybridization (FISH)": {"Amplification(s)": ["HER2", "MET"], "Structural Rearrangement(s)": ["RET"], "Deletion(s)": ["PTEN"]}, "Immunohistochemistry (IHC)": {"Expression": ["HER2", "PD-L1", "NTRK1", "NTRK2", "NTRK3"]}}
Keywords string
precision profile, solid tumors, neo type, NeoTYPE Precision Profile for Solid Tumors. NeoTYPE® Colorectal Tumor Profile
Title URL
neotype-colorectal-tumor-profile