NeoTYPE® GI Predictive Profile

Submitted by Anonymous (not verified) on
Code
NTG-GIPX-02CX
Panel
Active-Compendium
81457x1, 88360x2, 88342x1; add 88374x1 if HER2 IHC is reflexed to FISH; add 81479x1 if reflexed to NTRK NGS Fusion Panel (default) or 88374x3 automated (88377x3 manual) if reflexed to NTRK 1-3 FISH Panel
81479
Clinical
Oncology,Pathology
FFPE tissue: Paraffin block preferred. Please use 10% buffered formalin fixative. Do not use zinc fixatives.
Solid Tumors
Colorectal
Gastroesophageal
Next Generation Sequencing (NGS)
Global
Flag Active
True
Orderable Test Description
<p>The NeoTYPE GI Predictive Profile analyzes 10 biomarkers through a combination of next-generation sequencing (NGS), and IHC as listed below. Test orders include summary interpretation of all results to help guide treatment decisions. HER2 (Other) IHC w/Gastric Scoring (default) and HER2 Gastric/GEA options are available. If global HER2 (Other) IHC w/Gastric Scoring is selected and the result is 2+, the case will reflex to global HER2 (Other) FISH w/Gastric Scoring unless reflex to tech-only FISH or reflex opt-out is requested. If global HER2 Gastric/GEA is selected and the result is 2+, the case will reflex to global HER2 Gastric/GEA FISH unless reflex to tech-only FISH or reflex opt-out is requested. If Pan-TRK IHC is expressed or equivocal, reflex to either NTRK NGS Fusion Panel (Default) or NTRK 1-3 FISH Panel will be added. A microsatellite instability (MSI) NGS result of "indeterminate" will create a reflex to MSI by PCR as long as the tumor percentage is &ge;20% for colorectal specimens or &ge;40% with paired normal tissue available for non-colorectal specimens. NGS (5 genes + 2 biomarkers): BRAF, HRAS, KRAS, Microsatellite Instability (MSI), NRAS, TERT Promoter, Tumor Mutation Burden (TMB) IHC (3 biomarkers): HER2 (Other) w/Gastric Scoring (default) or HER2 Gastric/GEA, PD-L1 22C3, Pan-TRK (tech-only available for HER2 and PD-L1).</p>
Orderable Turn Around Time
14 Days; add 1-3 Days if reflexed to NTRK NGS Fusion Profile
Keywords
precision profile
solid tumors
neo type
NeoTYPE Precision Profile for Solid Tumors.
Meta Description
<p>The NeoTYPE GI Predictive Profile characterizes GI tumors of any histological subtype for the most significant genetic changes relevant to therapy decisions, prognosis, and clinical research.</p>
Extra Note

Use cold pack for transport, making sure cold pack is not in direct contact with specimen. NYS clients please provide date and time of Collection.

Orderable Biomarkers
HER2
NTRK1
NTRK2
NTRK3
PD-L1
HER2
MSI
TMB
HRAS
KRAS
TERT
NRAS
BRAF
NY Approved
True
Orderable Biomarkers JSON
{"DNA Sequencing": {"SNVs + Indels": ["HRAS", "KRAS", "TERT", "NRAS", "BRAF"], "Genomic Signatures": ["MSI", "TMB"]}, "Fluorescence In Situ Hybridization (FISH)": {"Amplification(s)": ["HER2"]}, "Immunohistochemistry (IHC)": {"Expression": ["HER2", "NTRK1", "NTRK2", "NTRK3", "PD-L1"]}}
Keywords string
precision profile, solid tumors, neo type, NeoTYPE Precision Profile for Solid Tumors. NeoTYPE® GI Predictive Profile
Title URL
neotype-gi-predictive-profile