Code
NTG-HNTX-02CX
Panel
Active-Compendium
81457x1, 88377x3, 88360x1, 88342x1, 88365x1; add 81194x1 if reflexed to NTRK NGS Fusion Panel (default) or 88374x3 automated (88377x3 manual) if reflexed to NTRK 1-3 FISH Panel
81479x1, 88377x3, 88360x1, 88342x1, 88365x1; add 81194x1 if reflexed to NTRK NGS Fusion Panel (default) or 88374x3 automated (88377x3 manual) if reflexed to NTRK 1-3 FISH Panel
Clinical
Oncology,Pathology
FFPE tissue: Paraffin block preferred. Please use 10% buffered formalin fixative. Do not use zinc fixatives.
Flag Active
True
Orderable Test Description
<p>The NeoTYPE Head & Neck Tumor Profile analyzes 34 biomarkers through a combination of next-generation sequencing (NGS), other molecular methods, FISH, and IHC as listed below. Test orders include summary interpretation of all results that help guide treatment decisions. If Pan-TRK IHC is expressed or equivocal, reflex to either NTRK NGS Fusion Panel (Default) or NTRK 1-3 FISH Panel will be added. A microsatellite instability (MSI) NGS result of "indeterminate" will create a reflex to MSI by PCR as long as the tumor percentage is ≥40% and paired normal tissue is available. NGS (27 genes + 2 biomarkers): AKT1, ATM, BRAF, CDKN2A, CTNNB1, EGFR, ERBB2, ERBB4, FBXW7, FGFR1, FGFR2, FGFR3, HRAS, IDH1, IDH2, KRAS, MET, Microsatellite Instability (MSI), NFE2L2, NOTCH1, NRAS, PIK3CA, PTEN, RB1, SMO, SRC, TERT Promoter, TP53, Tumor Mutation Burden (TMB) Other Methodology (1 biomarker): HPV RNA ISH 16/18 (High Risk) FISH (3 FISH): MET, PTEN, RET (tech-only available) IHC (2 biomarkers): PD-L1 22C3, Pan-TRK (tech-only available for PD-L1).</p>
Orderable Turn Around Time
14 Days
Extra Note
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. NYS clients please provide date and time of Collection.
Orderable Biomarkers
NY Approved
True
Orderable Biomarkers JSON
{"DNA Sequencing": {"SNVs + Indels": ["HRAS", "IDH1", "IDH2", "KRAS", "NRAS", "NOTCH1", "FBXW7", "NFE2L2", "RB1", "CDKN2A", "TERT", "AKT1", "ATM", "FGFR2", "FGFR3", "CTNNB1", "EGFR", "ERBB2", "ERBB4", "FGFR1", "MET", "SMO", "PIK3CA", "PTEN", "TP53", "SRC", "BRAF"], "Genomic Signatures": ["MSI", "TMB"]}, "Immunohistochemistry (IHC)": {"Expression": ["PD-L1", "NTRK1", "NTRK2", "NTRK3"]}, "Fluorescence In Situ Hybridization (FISH)": {"Amplification(s)": ["MET"], "Structural Rearrangement(s)": ["RET"], "Deletion(s)": ["PTEN"]}, "In Situ Hybridization (ISH)": {"Pathogen Detection": ["HPV 16/18"]}}
Keywords string
precision profile, solid tumors, neo type, NeoTYPE Precision Profile for Solid Tumors. NeoTYPE® Head & Neck Tumor Profile
Title URL
neotype-head-neck-tumor-profile