NeoTYPE® HRR Profile

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Code
NTG-HRRX-02CX
Panel
Active-Compendium
81445x1; 88360x1
81445
Clinical
Oncology,Pathology
FFPE tissue: Paraffin block preferred. Please use 10% buffered formalin fixative. Do not use zinc fixatives.
Solid Tumors
Breast
Ovary
Pancreas
Prostate
Next Generation Sequencing (NGS)
Global
Flag Active
True
Orderable Test Description
<p>The NeoTYPE HRR Profile analyzes 31 biomarkers through a combination of next-generation sequencing (NGS) and IHC as listed below. NGS (30 genes): ATM, ATR, BARD1, BRCA1, BRCA2, BRIP1, CDK12, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, FANCL, MLH1, MRE11A, MSH2, MSH6, NBN, PALB2, PMS2, RAD50, RAD51, RAD51B, RAD51C, RAD51D, RAD54L, TP53 IHC (1 biomarker): PD-L1 LDT (tech-only available for PD-L1).</p>
Orderable Turn Around Time
14 Days
Keywords
HRR
homologous recombination repair pathway
Meta Description
<p>Homologous recombination repair (HRR) is a pathway where mutations in genes involved in the repair of double-stranded DNA breaks have lost the ability to repair DNA and thus may lead to diseases such as cancer.</p>
Extra Note

Use cold pack for transport, making sure cold pack is not in direct contact with specimen. NYS clients please provide date and time of Collection.

Orderable Biomarkers
PD-L1
BRCA2
BRIP1
PALB2
RAD51C
ATM
ATR
BARD1
BRCA1
CDK12
CHEK1
CHEK2
FANCA
FANCC
FANCD2
FANCE
FANCF
FANCG
FANCL
MLH1
MRE11
MSH2
MSH6
NBN
PMS2
RAD50
RAD51
RAD51B
RAD51D
RAD54L
TP53
NY Approved
True
Orderable Biomarkers JSON
{"DNA Sequencing": {"SNVs + Indels": ["BRCA2", "BRIP1", "PALB2", "RAD51C", "ATM", "ATR", "BARD1", "BRCA1", "CDK12", "CHEK1", "CHEK2", "FANCA", "FANCC", "FANCD2", "FANCE", "FANCF", "FANCG", "FANCL", "MLH1", "MRE11", "MSH2", "MSH6", "NBN", "PMS2", "RAD50", "RAD51", "RAD51B", "RAD51D", "RAD54L", "TP53"]}, "Immunohistochemistry (IHC)": {"Expression": ["PD-L1"]}}
Keywords string
HRR, homologous recombination repair pathway NeoTYPE® HRR Profile
Title URL
neotype-hrr-profile