Code
NTG-IVFX-02AX
Panel
Active-Compendium
0388U
0388U (see NOTES for more info)
Clinical
Oncology,Pathology
Peripheral blood: two x 10 mL Streck Cell-Free DNA BCT® tubes
Flag Active
True
Orderable Test Description
<p>The InVisionFirst®-Lung liquid biopsy test is a 37-gene next-generation sequencing assay performed on cell-free circulating tumor DNA in peripheral blood to detect oncogenic driver mutations and therapy targets in non-small cell lung cancer (NSCLC). This assay demonstrated 98% concordance with tissue in clinical validation. </p>
<p>SNVs + indel hotspots: ALK, AKT1, BRAF, CCND1, CTNNB1, EGFR, ERBB2, ESR1, FGFR2, FGFR3, GATA3, GNA11, GNAQ, GNAS, HRAS, IDH1, IDH2, KRAS, KIT, MAP2K1, MET, MYC, NFE2L2, NRAS, NTRK1, NTRK3, PDGFRA, PIK3CA, PPP2R1A, ROS1, U2AF1 SNVs + indel exon coverage: PTEN (70%), CDKN2A, STK11, TP53 (88-100%) Fusions: ALK, NTRK1, RET, ROS1 CNV: EGFR, ERBB2, FGFR1, MET including exon 14 deletion</p>
<p>SNVs + indel hotspots: ALK, AKT1, BRAF, CCND1, CTNNB1, EGFR, ERBB2, ESR1, FGFR2, FGFR3, GATA3, GNA11, GNAQ, GNAS, HRAS, IDH1, IDH2, KRAS, KIT, MAP2K1, MET, MYC, NFE2L2, NRAS, NTRK1, NTRK3, PDGFRA, PIK3CA, PPP2R1A, ROS1, U2AF1 SNVs + indel exon coverage: PTEN (70%), CDKN2A, STK11, TP53 (88-100%) Fusions: ALK, NTRK1, RET, ROS1 CNV: EGFR, ERBB2, FGFR1, MET including exon 14 deletion</p>
Orderable Turn Around Time
7 Days
Keywords
Extra Note
Use cold pack for transport, making sure cold pack is not in direct contact with specimen.
Orderable Biomarkers
NY Approved
False
Orderable Biomarkers JSON
{"DNA Sequencing": {"SNVs + Indels": ["HRAS", "IDH1", "IDH2", "KIT", "KRAS", "NRAS", "MAP2K1", "STK11", "U2AF1", "ALK", "MYC", "NFE2L2", "CCND1", "PPP2R1A", "CDKN2A", "ROS1", "AKT1", "FGFR2", "FGFR3", "CTNNB1", "EGFR", "ERBB2", "ESR1", "NTRK1", "GATA3", "MET", "NTRK3", "GNA11", "PDGFRA", "PIK3CA", "GNAS", "GNAQ", "PTEN", "TP53", "BRAF"], "Splice Variant": ["MET exon 14 skipping", "MET exon 14 skippin"], "CNVs": ["ERBB2", "EGFR", "FGFR1"], "Fusions": ["ALK", "ROS1", "RET", "NTRK1"]}, "Fluorescence In Situ Hybridization (FISH)": {"Amplification(s)": ["MET"]}}
Keywords string
plasma testing, plasma test, ctDNA, cfDNA, CTC, ct-DNA, cf-DNA, cf DNA, ct DNA, liquid bx, invision, invision first, NSCLC InVisionFirst®-Lung Liquid Biopsy
Title URL
invisionfirst-lung-liquid-biopsy