NeoTYPE® Liver/Biliary Tumor Profile

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Code
NTG-LBTX-02CX
Panel
Active-Compendium
81457x1, 88377x3, 88360x1, 88342x1; add 81479x1 if reflexed to NTRK NGS Fusion Panel (default) or 88374x3 automated (88377x3 manual) if reflexed to NTRK 1-3 FISH Panel
81479
Clinical
Oncology,Pathology
FFPE tissue: Paraffin block preferred. Please use 10% buffered formalin fixative. Do not use zinc fixatives.
Solid Tumors
Biliary tract
Liver
Next Generation Sequencing (NGS)
Global
Flag Active
True
Orderable Test Description
<p>The NeoTYPE Liver/Biliary Tumor Profile analyzes 38 biomarkers through a combination of next-generation sequencing (NGS), FISH, and IHC as listed below. Test orders include summary interpretation of all results to help guide treatment decisions. If Pan-TRK IHC is expressed or equivocal, reflex to either NTRK NGS Fusion Panel (Default) or NTRK 1-3 FISH Panel will be added. A microsatellite instability (MSI) NGS result of "indeterminate" will create a reflex to MSI by PCR as long as the tumor percentage is &ge;40% and paired normal tissue is available. NGS (32 genes + 2 biomarkers): AKT1, APC, ARID1A, ATM, BAP1, BRAF, CDKN2A, CTNNB1, EGFR, ERBB2, ERBB4, FGFR1 (mutations), FGFR2 (mutations), FGFR3 (mutations), HRAS, IDH1, IDH2, KRAS, MET, Microsatellite Instability (MSI), NF1, NOTCH1, NRAS, PBRM1, PIK3CA, PTEN, SMAD4, SMO, SRC, TERT Promoter, TP53, TSC1, TSC2, Tumor Mutation Burden (TMB) FISH (3 FISH): FGFR2 rearrangement, MET, PTEN (tech-only available) IHC (2 biomarkers): PD-L1 LDT, Pan-TRK (tech-only available for PD-L1).</p>
Orderable Turn Around Time
14 Days
Keywords
neotype
Liver/Biliary
liver cancer
biliary cancer
cholangiocarcinoma
NeoTYPE Liver/Biliary Tumor Profile. IDH
Meta Description
This test is performed by sequencing the entire coding regions of the genes listed unless another method is noted. AKT1, ATM, BRAF, CDKN2A, CTNNB1, EGFR, ERBB2, ERBB4, FGFR1 (mutations), FGFR2 (mutations), FGFR3 (mutations), HRAS, IDH1, IDH2, KRAS, MET, NOTCH1, NRAS, PIK3CA, PTEN, SMAD4, SMO, SRC, TP53, MET FISH, PTEN FISH and PD-L1 IHC. Tumor Mutation Burden (TMB) testing and individual genes from a validated list of genes can be added. Test orders include summary interpretation of all results together. FISH components of NeoTYPE Profiles may be ordered as &quot;Tech-Only&quot; by pathology clients who wish to perform the professional component.
Extra Note

Use cold pack for transport, making sure cold pack is not in direct contact with specimen. NYS clients please provide date and time of Collection.

Orderable Biomarkers
FGFR2
PTEN
MET
PD-L1
NTRK1
NTRK3
NTRK2
MSI
TMB
HRAS
IDH1
IDH2
KRAS
NRAS
NOTCH1
NF1
CDKN2A
TERT
AKT1
ARID1A
ATM
FGFR2
FGFR3
CTNNB1
EGFR
ERBB2
ERBB4
SMAD4
FGFR1
MET
TSC1
TSC2
SMO
PIK3CA
PTEN
BRAF
APC
TP53
SRC
BAP1
PBRM1
NY Approved
True
Orderable Biomarkers JSON
{"DNA Sequencing": {"SNVs + Indels": ["HRAS", "IDH1", "IDH2", "KRAS", "NRAS", "NOTCH1", "NF1", "CDKN2A", "TERT", "AKT1", "ARID1A", "ATM", "FGFR2", "FGFR3", "CTNNB1", "EGFR", "ERBB2", "ERBB4", "SMAD4", "FGFR1", "MET", "TSC1", "TSC2", "SMO", "PIK3CA", "PTEN", "BRAF", "APC", "TP53", "SRC", "BAP1", "PBRM1"], "Genomic Signatures": ["MSI", "TMB"]}, "Immunohistochemistry (IHC)": {"Expression": ["PD-L1", "NTRK1", "NTRK3", "NTRK2"]}, "Fluorescence In Situ Hybridization (FISH)": {"Amplification(s)": ["MET"], "Deletion(s)": ["PTEN"], "Structural Rearrangement(s)": ["FGFR2"]}}
Keywords string
NeoTYPE, Liver/Biliary, liver cancer, biliary cancer, cholangiocarcinoma, NeoTYPE Liver/Biliary Tumor Profile. IDH NeoTYPE® Liver/Biliary Tumor Profile
Title URL
neotype-liver-biliary-tumor-profile