NeoTYPE® Melanoma Profile

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Code
NTG-MAPX-02CX
Panel
Active-Compendium
81457x1, 88377x1, 88360x1, 88342x1; add 81479x1 if reflexed to NTRK NGS Fusion Panel (default) or 88374x3 automated (88377x3 manual) if reflexed to NTRK 1-3 FISH Panel
81479
Clinical
Oncology,Pathology
FFPE tissue: Paraffin block (preferred). Please use 10% buffered formalin fixative. Do not use zinc fixatives.
Solid Tumors
Melanoma/Skin
Next Generation Sequencing (NGS)
Global
Flag Active
True
Orderable Test Description
<p>The NeoTYPE Melanoma Tumor Profile analyzes 30 biomarkers through a combination of next-generation sequencing (NGS), FISH, and IHC as listed below. Test orders include summary interpretation of all results to help guide treatment decisions. If Pan-TRK IHC is expressed or equivocal, reflex to either NTRK NGS Fusion Panel (Default) or NTRK 1-3 FISH Panel will be added. A microsatellite instability (MSI) NGS result of "indeterminate" will create a reflex to MSI by PCR as long as the tumor percentage is &ge;40% and paired normal tissue is available. NGS (24 genes + 2 biomarkers): AKT1, BAP1, BRAF, CDK4, CDKN2A, CTNNB1, EGFR, ERBB2, ERBB4, FGFR1, FGFR2, FGFR3, GNA11, GNAQ, HRAS, KIT, KRAS, Microsatellite Instability (MSI), NBN, NF1, NRAS, PDGFRA, SMO, SRC, TERT Promoter, Tumor Mutation Burden (TMB) FISH (1 FISH): PTEN (tech-only available) IHC (2 biomarkers): PD-L1 IHC, Pan-TRK (tech-only available for PD-L1).</p>
Orderable Turn Around Time
14 Days
Keywords
neo type
melanoma
melanoma profile
NeoTYPE Melanoma Profile
Meta Description
The NeoTYPE Melanoma Profile assesses the most commonly-mutated driver mutations in primary or metastatic melanoma to determine prognosis and identify established and clinical trial-based therapeutic options.
Extra Note

Use cold pack for transport, making sure cold pack is not in direct contact with specimen. NYS clients please provide date and time of Collection.

Orderable Biomarkers
PTEN
PD-L1
NTRK1
NTRK3
NTRK2
MSI
TMB
HRAS
KIT
KRAS
NRAS
NF1
CDK4
CDKN2A
TERT
AKT1
FGFR2
FGFR3
CTNNB1
EGFR
ERBB2
ERBB4
FGFR1
GNA11
PDGFRA
NBN
GNAQ
SMO
SRC
BAP1
BRAF
NY Approved
True
Orderable Biomarkers JSON
{"DNA Sequencing": {"SNVs + Indels": ["HRAS", "KIT", "KRAS", "NRAS", "NF1", "CDK4", "CDKN2A", "TERT", "AKT1", "FGFR2", "FGFR3", "CTNNB1", "EGFR", "ERBB2", "ERBB4", "FGFR1", "GNA11", "PDGFRA", "NBN", "GNAQ", "SMO", "SRC", "BAP1", "BRAF"], "Genomic Signatures": ["MSI", "TMB"]}, "Immunohistochemistry (IHC)": {"Expression": ["PD-L1", "NTRK1", "NTRK3", "NTRK2"]}, "Fluorescence In Situ Hybridization (FISH)": {"Deletion(s)": ["PTEN"]}}
Keywords string
neo type, melanoma, melanoma profile, NeoTYPE Melanoma Profile NeoTYPE® Melanoma Profile
Title URL
neotype-melanoma-profile