Code
NTG-MDSX-02BX
Panel
Active-Compendium
81455
81479
Clinical
Oncology,Pathology
Bone Marrow Aspirate: 2-3 mL in EDTA tube
Peripheral Blood: 3-5 mL in EDTA tube
FFPE tissue: Paraffin block. Alternatively, send 1 H&E slide plus 10-14 unstained slides cut at 5 or more microns. Please use positively-charged slides and 10% NBF fixative is the recommended fixative. Do not use zinc or mercury fixatives (B5). Highly acidic or prolonged decalcification processes will not yield sufficient nucleic acid to accurately perform molecular studies.
Note: Test in TNA-based. Please select Extract & Hold - TNA if specimen hold service is desired.
Peripheral Blood: 3-5 mL in EDTA tube
FFPE tissue: Paraffin block. Alternatively, send 1 H&E slide plus 10-14 unstained slides cut at 5 or more microns. Please use positively-charged slides and 10% NBF fixative is the recommended fixative. Do not use zinc or mercury fixatives (B5). Highly acidic or prolonged decalcification processes will not yield sufficient nucleic acid to accurately perform molecular studies.
Note: Test in TNA-based. Please select Extract & Hold - TNA if specimen hold service is desired.
Flag Active
True
Orderable Test Description
<p>The Neo Comprehensive- Myeloid Disorders assay analyzes 164 genes to detect DNA and RNA alterations through next-generation sequencing (NGS) as noted below. Test reports include a summary interpretation of all results together.</p>
<p>DNA sequencing SNVs/Indels (127 genes): ABL1, ANKRD26, APC, ARAF, ASXL1, ATM, ATRX, BCOR, BCORL1, BLM, BRAF, BRCA1, BRCA2, BRIP1, CALR, CBL, CBLB, CBLC, CDKN2A, CEBPA, CHEK2, CSF3R, CTC1, CUX1, CXCR4, DDX41, DKC1, DNMT3A, ELANE, EPCAM, ERCC4, ETNK1, ETV6, EZH2, FANCA, FANCB, FANCC, FANCD2, FANCE, FANCF, FANCG, FANCI, FANCL, FANCM, FBXW7, FLT3, G6PC3, GATA1, GATA2, GFI1, GNAS, GNB1, HAX1, HRAS, IDH1, IDH2, IKZF1, IKZF3, ITPKB, JAK2, JAK3, KDM6A, KIT, KMT2A, KRAS, MAP2K1, MET, MLH1, MPL, MSH2, MSH6, MYD88, NF1, NHP2, NOP10, NOTCH1, NPM1, NRAS, PALB2, PDGFRA, PHF6, PIGA, PML, PMS2, PRPF8, PPM1D, PTEN, PTPN11, RAD21, RAD51C, RB1, RPL11, RPL35A, RPL5, RPS10, RPS17, RPS26, RPS7, RTEL1, RUNX1, SAMD9, SAMD9L, SBDS, SETBP1, SETD2, SF3B1, SH2B3, SLX4, SMC1A, SMC3, SRP72, SRSF2, STAG2, STAT3, STAT5B, SUZ12, TERC, TERT, TET2, TINF2, TP53, U2AF1, VHL, WAS, WRAP53, WT1, ZRSR2 </p>
<p>Copy Number Variants (CNV) (17 genes): ABL1, ASXL1, ATG2B, BRAF, CBFB, CDKN1B, CDKN2A, DNMT1, ETV6, EZH2, GSKIP, JAK2, KMT2A, KRAS, MYC, RAD21, TP53</p>
<p>RNA sequencing Fusions (40 genes): ABL1, AFDN, AFF1, ALK, BCL11B, CBFB, CEP43, CPSF6, CREBBP, DEK, ELL, EP300, ETV6, FGFR1, FLT3, GLIS2, JAK2, KMT2A, MECOM, MLLT1, MLLT3, MRTFA, MYB, MYH11, NTRK3, NUP214, NUP98, PCM1, PDGFRA, PDGFRB, PICALM, PML, PRDM16, RARA, RBM15, RPN1, RUNX1, RUNX1T1, TCF3, ZNF384</p>
<p>Note: FLT3 by PCR (via FLT3 Mutation Analysis) is available to be ordered, as Client-Bill only, in conjunction with the Neo Comprehensive Myeloid Disorders. It is reported separately from the Neo Comprehensive profile for the purpose of prompt therapy selection in patients with a new diagnosis of AML.</p>
<p>DNA sequencing SNVs/Indels (127 genes): ABL1, ANKRD26, APC, ARAF, ASXL1, ATM, ATRX, BCOR, BCORL1, BLM, BRAF, BRCA1, BRCA2, BRIP1, CALR, CBL, CBLB, CBLC, CDKN2A, CEBPA, CHEK2, CSF3R, CTC1, CUX1, CXCR4, DDX41, DKC1, DNMT3A, ELANE, EPCAM, ERCC4, ETNK1, ETV6, EZH2, FANCA, FANCB, FANCC, FANCD2, FANCE, FANCF, FANCG, FANCI, FANCL, FANCM, FBXW7, FLT3, G6PC3, GATA1, GATA2, GFI1, GNAS, GNB1, HAX1, HRAS, IDH1, IDH2, IKZF1, IKZF3, ITPKB, JAK2, JAK3, KDM6A, KIT, KMT2A, KRAS, MAP2K1, MET, MLH1, MPL, MSH2, MSH6, MYD88, NF1, NHP2, NOP10, NOTCH1, NPM1, NRAS, PALB2, PDGFRA, PHF6, PIGA, PML, PMS2, PRPF8, PPM1D, PTEN, PTPN11, RAD21, RAD51C, RB1, RPL11, RPL35A, RPL5, RPS10, RPS17, RPS26, RPS7, RTEL1, RUNX1, SAMD9, SAMD9L, SBDS, SETBP1, SETD2, SF3B1, SH2B3, SLX4, SMC1A, SMC3, SRP72, SRSF2, STAG2, STAT3, STAT5B, SUZ12, TERC, TERT, TET2, TINF2, TP53, U2AF1, VHL, WAS, WRAP53, WT1, ZRSR2 </p>
<p>Copy Number Variants (CNV) (17 genes): ABL1, ASXL1, ATG2B, BRAF, CBFB, CDKN1B, CDKN2A, DNMT1, ETV6, EZH2, GSKIP, JAK2, KMT2A, KRAS, MYC, RAD21, TP53</p>
<p>RNA sequencing Fusions (40 genes): ABL1, AFDN, AFF1, ALK, BCL11B, CBFB, CEP43, CPSF6, CREBBP, DEK, ELL, EP300, ETV6, FGFR1, FLT3, GLIS2, JAK2, KMT2A, MECOM, MLLT1, MLLT3, MRTFA, MYB, MYH11, NTRK3, NUP214, NUP98, PCM1, PDGFRA, PDGFRB, PICALM, PML, PRDM16, RARA, RBM15, RPN1, RUNX1, RUNX1T1, TCF3, ZNF384</p>
<p>Note: FLT3 by PCR (via FLT3 Mutation Analysis) is available to be ordered, as Client-Bill only, in conjunction with the Neo Comprehensive Myeloid Disorders. It is reported separately from the Neo Comprehensive profile for the purpose of prompt therapy selection in patients with a new diagnosis of AML.</p>
Orderable Turn Around Time
14 Days
Extra Note
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. NYS clients please provide date and time of Collection. Please select Extract & Hold - TNA if specimen hold service is desired.
Orderable Biomarkers
NY Approved
True
Orderable Biomarkers JSON
{"DNA Sequencing": {"SNVs + Indels": ["KDM6A", "MAP2K1", "MPL", "PPM1D", "NF1", "RAD21", "RB1", "SETD2", "SMC1A", "SMC3", "STAT3", "STAT5B", "VHL", "SUZ12", "CBLB", "CBLC", "ABL1", "CDKN2A", "ETNK1", "FANCB", "FANCM", "FLT3", "GNB1", "IKZF1", "JAK2", "JAK3", "IKZF3", "ITPKB", "ANKRD26", "PDGFRA", "SH2B3", "TP53", "ASXL1", "BCOR", "BRAF", "CEBPA", "CSF3R", "DNMT3A", "ETV6", "EZH2", "HRAS", "CALR", "IDH2", "PIGA", "KMT2A", "IDH1", "NPM1", "PHF6", "PML", "PRPF8", "RUNX1", "SF3B1", "PTPN11", "STAG2", "WT1", "U2AF1", "ZRSR2", "SETBP1", "BRIP1", "BRCA2", "RTEL1", "DDX41", "DKC1", "SAMD9", "ELANE", "SAMD9L", "SBDS", "CTC1", "ERCC4", "G6PC3", "KIT", "GFI1", "HAX1", "NHP2", "NOP10", "PALB2", "CUX1", "RAD51C", "RPL11", "KRAS", "RPL35A", "RPL5", "RPS10", "RPS17", "RPS26", "RPS7", "NRAS", "SLX4", "SRP72", "TERC", "TERT", "TINF2", "WAS", "WRAP53", "ATM", "BRCA1", "CHEK2", "FANCA", "FANCC", "FANCD2", "FANCE", "FANCF", "FANCI", "FANCL", "SRSF2", "FANCG", "MET", "MLH1", "MSH2", "MSH6", "TET2", "PMS2", "PTEN", "APC", "CXCR4", "MYD88", "NOTCH1", "EPCAM", "FBXW7", "ATRX", "ARAF", "BCORL1", "BLM", "CBL", "GATA1", "GATA2", "GNAS"], "CNVs": ["ABL1", "ASXL1", "CDKN1B", "DNMT1", "CDKN2A", "ETV6", "EZH2", "KMT2A", "TP53", "RAD21", "ATG2B", "GSKIP", "JAK2", "KRAS"]}, "RNA Sequencing": {"Fusions": ["PCM1", "PML", "RARA", "RUNX1T1", "ALK", "MYB", "BCL11B", "CBFB", "CEP43", "CPSF6", "MYH11", "DEK", "ABL1", "EP300", "ETV6", "FGFR1", "FLT3", "JAK2", "KMT2A", "AFDN", "AFF1", "NTRK3", "NUP98", "PDGFRA", "MECOM", "PDGFRB", "RUNX1", "MRTFA", "TCF3", "ZNF384", "PICALM", "PRDM16", "RBM15", "RPN1", "CREBBP", "ELL", "GLIS2", "MLLT1", "MLLT3", "NUP214"]}, "Fluorescence In Situ Hybridization (FISH)": {"Amplification(s)": ["MYC"], "CNVs": ["CBFB"], "Structural Rearrangement(s)": ["BRAF"]}}
Keywords string
Myeloid CGP Comprehensive genomic profiling heme NGS Neo Comprehensive - Myeloid Disorders
Title URL
neo-comprehensive-myeloid-disorders