NeoTYPE® Other Solid Tumor Profile

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Code
NTG-OSTX-02CX
Panel
Active-Compendium
81457x1, 81479x1, 88377x2, 88360x1, 88342x1; add 81479x1 if reflexed to NTRK NGS Fusion Panel (default) or 88374x3 automated (88377x3 manual) if reflexed to NTRK 1-3 FISH Panel
81479
Clinical
Oncology,Pathology
FFPE tissue: Paraffin block preferred. Please use 10% buffered formalin fixative. Do not use zinc fixatives.
Solid Tumors
Adrenal gland
Biliary tract
Bladder
Breast
Central nervous system (CNS)
Cervix
Colorectal
Endometrium
Gastroesophageal
GIST/Soft Tissue
Kidney
Liver
Lung
Melanoma/Skin
Ovary
Pancreas
Prostate
Salivary Gland
Thyroid
Upper Aerodigestive tract
Next Generation Sequencing (NGS)
Global
Flag Active
True
Orderable Test Description
<p>The NeoTYPE Other Solid Tumor Profile analyzes 30 biomarkers through a combination of next-generation sequencing (NGS), FISH, and IHC as listed below. Test orders include summary interpretation of all results to help guide treatment decisions. If Pan-TRK IHC is expressed or equivocal, reflex to either NTRK NGS Fusion Panel (Default) or NTRK 1-3 FISH Panel will be added. A microsatellite instability (MSI) NGS result of "indeterminate" will create a reflex to MSI by PCR as long as the tumor percentage is &ge;20% for colorectal specimens or &ge;40% with paired normal tissue available for non-colorectal specimens. NGS (24 genes + 2 biomarkers): AKT1, BRAF, EGFR, FGFR1, FGFR2, FGFR3, GNAS, HRAS, IDH1, IDH2, KIT, KRAS, MET, Microsatellite Instability (MSI), NOTCH1, NRAS, PDGFRA, PIK3CA, PTEN, PTPN11, SMAD4, SMO, SRC, TERT Promoter, TP53, Tumor Mutation Burden (TMB) FISH (2 FISH): MET, PTEN (tech-only available) IHC (2 biomarkers): PD-L1 LDT, Pan-TRK (tech-only available for PD-L1).</p>
Orderable Turn Around Time
14 Days
Keywords
Other Solid Tumor
neotype
solid
neo type
NeoTYPE Other Solid Tumor Profile.
Meta Description
The NeoTYPE Other Solid Tumor Profile characterizes primary or metastatic tumors of any histological subtype for the most significant genetic changes relevant to therapy decisions, prognosis, and clinical research.
Extra Note

Use cold pack for transport, making sure cold pack is not in direct contact with specimen. NYS clients please provide date and time of Collection.

Orderable Biomarkers
PD-L1
NTRK1
NTRK2
NTRK3
MSI
TMB
HRAS
IDH1
IDH2
KIT
KRAS
NRAS
NOTCH1
PTPN11
TERT
AKT1
FGFR2
FGFR3
EGFR
TP53
FGFR1
MET
PDGFRA
PIK3CA
GNAS
PTEN
SMAD4
SMO
SRC
BRAF
NY Approved
True
Orderable Biomarkers JSON
{"DNA Sequencing": {"SNVs + Indels": ["HRAS", "IDH1", "IDH2", "KIT", "KRAS", "NRAS", "NOTCH1", "PTPN11", "TERT", "AKT1", "FGFR2", "FGFR3", "EGFR", "TP53", "FGFR1", "MET", "PDGFRA", "PIK3CA", "GNAS", "PTEN", "SMAD4", "SMO", "SRC", "BRAF"], "Genomic Signatures": ["MSI", "TMB"]}, "Immunohistochemistry (IHC)": {"Expression": ["PD-L1", "NTRK1", "NTRK2", "NTRK3"]}}
Keywords string
Other Solid Tumor, neotype, solid, neo type, NeoTYPE Other Solid Tumor Profile. NeoTYPE® Other Solid Tumor Profile
Title URL
neotype-other-solid-tumor-profile