Code
APG-PANX-01AX
Test
Active-Compendium
88342 x 1 or 88341 x 1
Clinical
Oncology,Pathology
A formalin-fixed, paraffin-embedded (FFPE) tissue block is preferred specimen type or one (1) unbaked, unstained slide for H&E staining (required) and two to three (2-3) positively charged unstained slides (all cut at 4-5 microns) for each test/antibody ordered.
Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Flag Active
True
Orderable Test Description
<p>Pan-TRK (clone EPR17341) is directed against the C-terminal region of TRK (tropomyosin receptor kinase) A, B, and C proteins, which are encoded by NTRK1, NTRK2, and NTRK3 genes respectively. Pan-TRK IHC staining is a useful screen for identification of NTRK protein overexpression caused by gene fusions. Correlation of IHC staining with molecular detection of TRK fusions is moderate; discrepant cases have been described. IHC screening is not recommended in neuroendocrine tumors, GISTs, gliomas, or adult sarcomas, as these tissues show positive staining in the absence of an NTRK translocation. Published sensitivity rates of IHC staining for detection of NTRK fusions (detected by molecular testing) are 95% and above. Follow-up molecular testing is available to confirm positivity and identify the specific NTRK gene rearranged and its fusion partner gene.</p>
Orderable Turn Around Time
2 Day
Keywords
Extra Note
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. NYS clients please provide date and time of Collection.
NY Approved
True
Orderable Biomarkers JSON
{"Immunohistochemistry (IHC)": {"Expression": ["NTRK1", "NTRK2", "NTRK3"]}}
Keywords string
neurotrophin, larotrectinib, Vitrakvi, panTRK, pan TRK, pan, TRK Pan-TRK
Title URL
pan-trk